Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines
- Авторы: Paronikyan E.G.1, Dashyan S.S.1, Dzhagatspanyan I.A.1, Paronikyan R.G.1, Nazaryan I.M.1, Akopyan A.G.1, Minasyan N.S.2, Ayvazyan A.G.2, Tamazyan R.A.2, Babaev E.V.3
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Учреждения:
- Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center
- Moscow State University
- Выпуск: Том 42, № 2 (2016)
- Страницы: 215-223
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227893
- DOI: https://doi.org/10.1134/S1068162016020102
- ID: 227893
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Аннотация
New diamino derivatives of pyrano[3,4-c]pyridines were synthesized by the pyridine ring recyclization. The presence of the intramolecular hydrogen bond in 6-[(4-methoxyphenyl)amino]-3,3-dimethyl8-methylamino-3,4-dihydro-1H-pyrano[3,4-c]pyridin-5-carbonitrile was identified by X-ray diffraction. A pharmacological study of the synthesized compounds was carried out in known tests, such as assay for antagonism induced by corazole subcutaneous injection and the open field test. The method of rotating rod was used to evaluate neurotoxicity. The diamino derivatives of pyrano[3,4-c]pyridines were found to possess neutrotropic properties. The synthesized compounds, as well as diazepam, prevent the occurrence of clonic seizures and clonic corazoleinduced convulsions in animals; however, they cause a behavior-depressing sedative effect.
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Об авторах
E. Paronikyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
Sh. Dashyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Автор, ответственный за переписку.
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
I. Dzhagatspanyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
R. Paronikyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
I. Nazaryan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
A. Akopyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
N. Minasyan
Molecular Structure Research Center
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
A. Ayvazyan
Molecular Structure Research Center
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
R. Tamazyan
Molecular Structure Research Center
Email: shdashyan@gmail.com
Армения, pr. Azatutyan 26, Yerevan, 0014
E. Babaev
Moscow State University
Email: shdashyan@gmail.com
Россия, Moscow, 119991
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