Synthesis and Biological Evaluation of Novel Steroidal 5α,8α-Endoperoxide Derivatives with Aromatic Hydrazone Side Chain as Potential Anticancer Agents
- Authors: Wang H.J.1, Bu M.1, Wang J.1, Liu L.1, Zhang S.2
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Affiliations:
- College of Pharmacy, Qiqihar Medical University
- Basic Medical Science College, Qiqihar Medical University
- Issue: Vol 45, No 6 (2019)
- Pages: 585-590
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229260
- DOI: https://doi.org/10.1134/S1068162019060396
- ID: 229260
Cite item
Abstract
Seven new steroidal 5α,8α-endoperoxide derivatives with C-17 aromatic hydrazone side chain were synthesized. Structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectrometry. Anti-proliferative activities of the synthesized compounds were evaluated in vitro by the MTT method. Among the seven compounds, 5α,8α-epidioxy-17-(4-chloro-benzylidene)-hydrazonoandrost-3β-ol showed the strongest anti-proliferative activity against three human cancer cell lines (MCF-7, HepG2, and SK-Hep1).
About the authors
H. J. Wang
College of Pharmacy, Qiqihar Medical University
Email: buming@qmu.edu.cn
China, Qiqihar, 161006
M. Bu
College of Pharmacy, Qiqihar Medical University
Author for correspondence.
Email: buming@qmu.edu.cn
China, Qiqihar, 161006
J. Wang
College of Pharmacy, Qiqihar Medical University
Email: buming@qmu.edu.cn
China, Qiqihar, 161006
L. Liu
College of Pharmacy, Qiqihar Medical University
Email: buming@qmu.edu.cn
China, Qiqihar, 161006
S. Zhang
Basic Medical Science College, Qiqihar Medical University
Email: buming@qmu.edu.cn
China, Qiqihar, 161006