Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids
- Authors: Kazakova O.B.1, Smirnova I.E.1, Baltina L.A.1, Boreko E.I.2, Savinova O.V.2, Pokrovskii A.G.3
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Affiliations:
- Ufa Institute of Chemistry, Autonomous Structural Unit of the Ufa Federal Research Centre
- Republican Research and Practice Center for Epidemiology and Microbiology
- Vector State Research Center of Virology and Biotechnology
- Issue: Vol 44, No 6 (2018)
- Pages: 740-744
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229058
- DOI: https://doi.org/10.1134/S1068162018050059
- ID: 229058
Cite item
Abstract
The paper reports on the synthesis of a series of acyl derivatives of betulin and dihydroquinopimaric acid and the study of their antiviral activity against influenza A virus (H7N1), herpes simplex virus type 1 (HSV-1), ECHO 6, and HIV-1 in comparison with the activity of the previously obtained acylates and original terpenoids. It has been demonstrated that acylated betulin and betulinic acid show no advantage in inhibiting the reproduction of all the tested viruses compared with the betulic acid, while structural modifications at positions C3 and C28 of the triterpene core led to some changes in the spectrum of antiviral activity. Modification of dihydroquinopimaric acid at position C4 increased the activity of this compound against influenza virus A (H7N1).
Keywords
About the authors
O. B. Kazakova
Ufa Institute of Chemistry, Autonomous Structural Unit of the Ufa Federal Research Centre
Author for correspondence.
Email: obf@anrb.ru
Russian Federation, Ufa, 450054
I. E. Smirnova
Ufa Institute of Chemistry, Autonomous Structural Unit of the Ufa Federal Research Centre
Email: obf@anrb.ru
Russian Federation, Ufa, 450054
L. A. Baltina
Ufa Institute of Chemistry, Autonomous Structural Unit of the Ufa Federal Research Centre
Email: obf@anrb.ru
Russian Federation, Ufa, 450054
E. I. Boreko
Republican Research and Practice Center for Epidemiology and Microbiology
Email: obf@anrb.ru
Belarus, Minsk, 220114
O. V. Savinova
Republican Research and Practice Center for Epidemiology and Microbiology
Email: obf@anrb.ru
Belarus, Minsk, 220114
A. G. Pokrovskii
Vector State Research Center of Virology and Biotechnology
Email: obf@anrb.ru
Russian Federation, Kоltsovo, Novosibirsk oblast, 630059