Synthesis and Anti-Infective Activity of 2-Heteroaryl(Acyl)-9,10,12,13-Tetramethoxy-3-Methyl-4,5-Dihydro-3H-Phenanthro[1,2-d]Azepines
- Authors: Zubenko A.A.1, Divaeva L.N.2, Morkovnik A.S.2, Kartsev V.G.3, Drobin Y.D.1, Serbinovskaya N.M.1, Fetisov L.N.1, Bodryakov A.N.1, Bodryakova M.A.1, Lyashenko L.A.1, Klimenko A.I.4
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Affiliations:
- Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
- Institute of Organic and Physical Chemistry
- InterBioScreen Ltd
- Don State Agrarian University
- Issue: Vol 44, No 4 (2018)
- Pages: 461-468
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228988
- DOI: https://doi.org/10.1134/S1068162018040192
- ID: 228988
Cite item
Abstract
2-Hetaryl- and 2-acyl-9,10,12,13-tetramethoxy-3-methyl-4,5-dihydro-3H-phenanthro[1,2-d]-azepines have been synthesized from 8,9,11,12-tetramethoxy-2-methyl-3,4-dihydronaphtho[2,1-f]isoquinolinium perchlorate by pyridine-azepine recyclization. The resulting compounds have revealed a pronounced antibacterial activity against Staphylococcus aureus (strain P-209) and Escherichia coli (field strain 078). Some of these compounds have a moderate fungistatic activity against Peniciliium italicum fungi. Two compounds have shown a certain activity in relation to the Colpoda steinii protozoa.
Keywords
About the authors
A. A. Zubenko
Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
L. N. Divaeva
Institute of Organic and Physical Chemistry
Author for correspondence.
Email: divaevaln@mail.ru
Russian Federation, Rostov-on-Don, 344090
A. S. Morkovnik
Institute of Organic and Physical Chemistry
Email: divaevaln@mail.ru
Russian Federation, Rostov-on-Don, 344090
V. G. Kartsev
InterBioScreen Ltd
Email: divaevaln@mail.ru
Russian Federation, Moscow region, Chernogolovka
Y. D. Drobin
Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
N. M. Serbinovskaya
Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
L. N. Fetisov
Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
A. N. Bodryakov
Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
M. A. Bodryakova
Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
L. A. Lyashenko
Scientific Institution North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
A. I. Klimenko
Don State Agrarian University
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk