New Targets for Growth Inhibition of Mycobacterium tuberculosis: Why Do Natural Terpenoids Exhibit Antitubercular Activity?
- Authors: Kataev V.E.1, Khaybullin R.N.1, Garifullin B.F.1, Sharipova R.R.1
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Affiliations:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
- Issue: Vol 44, No 4 (2018)
- Pages: 438-452
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228979
- DOI: https://doi.org/10.1134/S1068162018040106
- ID: 228979
Cite item
Abstract
The article draws the attention of chemists to the literature data reporting the discovery of new targets for growth inhibition of Mycobacterium tuberculosis, namely, diterpene cyclase (Rv3377c) and tuberculosinol phosphatase (Rv3378c), which produce diterpenoids of tuberculosinols in the cell membrane of M. tuberculosis, and these diterpenoids ensure the pathogenicity and the virulence of M. tuberculosis. For the first time, by the example of diterpenoid of isosteviol, its binuclear derivatives, triterpenoid betulinic, oleanolic, and ursolic acids, it has been shown by the molecular docking method that the antitubercular activity of natural terpenoids is caused by their ability to bind to the active site of tuberculosinol phosphatase (Rv3378c) of M. tuberculosis. It is suggested that natural and semisynthetic terpenoids represent a promising platform for design of a new generation of antitubercular agents that affect this enzyme.
About the authors
V. E. Kataev
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Author for correspondence.
Email: kataev@iopc.ru
Russian Federation, Kazan, 420088
R. N. Khaybullin
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Russian Federation, Kazan, 420088
B. F. Garifullin
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Russian Federation, Kazan, 420088
R. R. Sharipova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Russian Federation, Kazan, 420088