A New Iq-Peptide of the Kunitz Type from the Heteractis magnifica Sea Anemone Exhibits Neuroprotective Activity in a Model of Alzheimer’s Disease


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The HMIQ3c1 recombinant peptide (6434 Da), the Kunitz-type protease inhibitor, which belonged to the new group of the IQ-peptides from the Heteractis magnifica sea anemone was prepared. The inhibitory constant of trypsin by this peptide proved to be 5.0 × 10–8 M. rHMIQ3c1 was shown to have no interaction with eight isoforms of Kv1 channels. This peptide exhibited neuroprotective activity in a concentration of 10 μM, and the peptide increased the viability of cells of the Neuro2a murine neuroblastoma by 39.4 ± 6.6% in the presence of β-amyloid. However, the peptide did not influence the viability of the cells during their incubation with 6-hydroxydofamine.

作者简介

A. Kvetkina

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch

Email: leychenko@gmail.com
俄罗斯联邦, Vladivostok, 690022

E. Leychenko

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch; School of Natural Sciences

编辑信件的主要联系方式.
Email: leychenko@gmail.com
俄罗斯联邦, Vladivostok, 690022; Vladivostok, 690090

E. Yurchenko

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch

Email: leychenko@gmail.com
俄罗斯联邦, Vladivostok, 690022

E. Pislyagin

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch

Email: leychenko@gmail.com
俄罗斯联邦, Vladivostok, 690022

S. Peigneur

Catholic University of Leuven

Email: leychenko@gmail.com
比利时, Leuven, 3000

Y. Tytgat

Catholic University of Leuven

Email: leychenko@gmail.com
比利时, Leuven, 3000

M. Isaeva

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch; School of Natural Sciences

Email: leychenko@gmail.com
俄罗斯联邦, Vladivostok, 690022; Vladivostok, 690090

D. Aminin

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch

Email: leychenko@gmail.com
俄罗斯联邦, Vladivostok, 690022

E. Kozlovskaya

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch

Email: leychenko@gmail.com
俄罗斯联邦, Vladivostok, 690022

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