Impact of Noncoding Part of the Genome on the Proteome Plasticity of the Eukaryotic Cell
- Autores: Fesenko I.A.1, Kirov I.V.1, Filippova A.A.1
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Afiliações:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Edição: Volume 44, Nº 4 (2018)
- Páginas: 397-402
- Seção: Mini-Review
- URL: https://journals.rcsi.science/1068-1620/article/view/228961
- DOI: https://doi.org/10.1134/S1068162018040076
- ID: 228961
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Resumo
Recent studies revealed that about 80% of the eukaryotic genome is biochemically active; it produces not solely mRNA but also a large number of noncoding RNAs (ncRNAs). Thus, a large fraction of “ribonome” (the total cellular complement of RNAs and their regulatory factors) of the cell consists of a variety of noncoding RNAs (ncRNAs), while mRNAs occupy only a small part of it. It is well known that long noncoding RNAs (lncRNAs) are involved in the regulation of protein-coding gene expression by altering the chromatin structure, transcription regulation, and pre-mRNA splicing. MicroRNAs and small interfering RNAs trigger the RNA interference mechanism involved in the transcriptional and post-transcriptional regulation of gene expression. However, our knowledge of the role of noncoding part of the genome in proteome diversification and plasticity is scarce. In this mini-review, we discuss new data obtained over the past few years, which change our view of the role of noncoding part of the genome in the cell proteome formation.
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Sobre autores
I. Fesenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Autor responsável pela correspondência
Email: fesigor@gmail.com
Rússia, Moscow, 119779
I. Kirov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: fesigor@gmail.com
Rússia, Moscow, 119779
A. Filippova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: fesigor@gmail.com
Rússia, Moscow, 119779
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