Impact of Noncoding Part of the Genome on the Proteome Plasticity of the Eukaryotic Cell


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Recent studies revealed that about 80% of the eukaryotic genome is biochemically active; it produces not solely mRNA but also a large number of noncoding RNAs (ncRNAs). Thus, a large fraction of “ribonome” (the total cellular complement of RNAs and their regulatory factors) of the cell consists of a variety of noncoding RNAs (ncRNAs), while mRNAs occupy only a small part of it. It is well known that long noncoding RNAs (lncRNAs) are involved in the regulation of protein-coding gene expression by altering the chromatin structure, transcription regulation, and pre-mRNA splicing. MicroRNAs and small interfering RNAs trigger the RNA interference mechanism involved in the transcriptional and post-transcriptional regulation of gene expression. However, our knowledge of the role of noncoding part of the genome in proteome diversification and plasticity is scarce. In this mini-review, we discuss new data obtained over the past few years, which change our view of the role of noncoding part of the genome in the cell proteome formation.

Sobre autores

I. Fesenko

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Autor responsável pela correspondência
Email: fesigor@gmail.com
Rússia, Moscow, 119779

I. Kirov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: fesigor@gmail.com
Rússia, Moscow, 119779

A. Filippova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: fesigor@gmail.com
Rússia, Moscow, 119779

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