The cardioprotective and antioxidant effects of dimethyl-5-(bioguanide-1-il)isophthalate under the conditions of cardiovascular pathology and experimental rheumatoid arthritis in rats
- Authors: Shulgin K.K.1, Semenikhina A.V.1, Kryl’skiy D.V.2, Popova T.N.1, Safonova O.A.1, Kryl’skiy E.D.1
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Affiliations:
- Voronezh State University
- Applied Acoustics Research Institute
- Issue: Vol 43, No 4 (2017)
- Pages: 443-448
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228605
- DOI: https://doi.org/10.1134/S1068162017040082
- ID: 228605
Cite item
Abstract
Using predictive computer software PASS, the antioxidant and cardioprotective properties of dimethyl-5-(bioguanide-1-il)isophthalate have been predicted. This substance was synthesized and tested in rats with experimental rheumatoid arthritis. We studied the indices of pathology progression, such as content of rheumatoid factor, erythrocyte sedimentation rate, contents of circulating immune complexes and immunoglobulins A, M, and G, activity of aspartate aminotransferase and myocardial creatine kinase, indices of intensity of free radical processes, including content of diene conjugates and activity of aconitase, and indices of apoptosis, such as activity of caspases, phosphatidylserine externalization, and DNA fragmentation. Administration of dimethyl-5-(bioguanide-1-il)isophthalate to rats with experimental cardiovascular pathology resulted in a shift of all indices studied to the control values that indicated the cardioprotective and antioxidant properties of the substance. In most cases the protective effect was dose-dependent. These data are interesting for the development of new approaches for therapy of rheumatoid arthritis.
About the authors
K. K. Shulgin
Voronezh State University
Email: solya333@mail.ru
Russian Federation, Voronezh, Voronezh oblast, 394006
A. V. Semenikhina
Voronezh State University
Email: solya333@mail.ru
Russian Federation, Voronezh, Voronezh oblast, 394006
D. V. Kryl’skiy
Applied Acoustics Research Institute
Email: solya333@mail.ru
Russian Federation, Dubna, Moscow oblast, 141981
T. N. Popova
Voronezh State University
Email: solya333@mail.ru
Russian Federation, Voronezh, Voronezh oblast, 394006
O. A. Safonova
Voronezh State University
Author for correspondence.
Email: solya333@mail.ru
Russian Federation, Voronezh, Voronezh oblast, 394006
E. D. Kryl’skiy
Voronezh State University
Email: solya333@mail.ru
Russian Federation, Voronezh, Voronezh oblast, 394006