Synthesis of functionalized benzo[f]2H-chromenes and evaluation of their antimicrobial activities
- Authors: Chanu I.H.1, Devi L.R.2, Khumanthem N.3, Singh N.I.3, Kumar D.1, Singh O.M.1
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Affiliations:
- Department of Chemistry
- Department of Basic Science and Humanities
- Department of Life Science
- Issue: Vol 43, No 2 (2017)
- Pages: 177-185
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228474
- DOI: https://doi.org/10.1134/S1068162017020054
- ID: 228474
Cite item
Abstract
Knoevenagel cyclocondensations of α-hydroxy naphthaldehyde with β-oxodithioesters and ketene dithioacetals yielded 2H-benzo[f]chromene-2-thiones and 2H-benzo[f]chromen-2-ones, respectively, in high yields. The newly synthesized compounds were evaluated for antifungal and antibacterial activities. Among them, compounds (2-furyl)(3-thioxo-3H-benzo[f]chromen-2-yl)methanone and phenyl(3-oxo-3H-benzo[f]chromen-2-yl)methanone exhibited excellent antifungal activity against tested fungi Curvularia lunata and Fusarium moniliforme. The highest antibacterial activity against the tested bacteria Escherichia coli and Staphylococcus aureus was observed for (4-chlorophenyl)(3-oxo-3H-benzo[f]chromen-2-yl)methanone. The results of antimicrobial screening demonstrate that (2-furyl)(3-thioxo-3H-benzo[f]chromen-2-yl)methanone, phenyl(3-oxo-3H-benzo[f]chromen-2-yl)methanone, and (4-chlorophenyl)(3-oxo-3H-benzo[f]chromen-2-yl)methanone are promising as antimicrobial drugs.
About the authors
Irom Harimala Chanu
Department of Chemistry
Email: ok_mukherjee@yahoo.co.in
India, Canchipur, 795003
Laishram Ronibala Devi
Department of Basic Science and Humanities
Email: ok_mukherjee@yahoo.co.in
India, Imphal, 795004
Nonibala Khumanthem
Department of Life Science
Email: ok_mukherjee@yahoo.co.in
India, Canchipur, 795003
N. Irabanta Singh
Department of Life Science
Email: ok_mukherjee@yahoo.co.in
India, Canchipur, 795003
Dalip Kumar
Department of Chemistry
Email: ok_mukherjee@yahoo.co.in
India, Pilani, 333031
Okram Mukherjee Singh
Department of Chemistry
Author for correspondence.
Email: ok_mukherjee@yahoo.co.in
India, Canchipur, 795003