Synthesis of functionalized benzo[f]2H-chromenes and evaluation of their antimicrobial activities


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Resumo

Knoevenagel cyclocondensations of α-hydroxy naphthaldehyde with β-oxodithioesters and ketene dithioacetals yielded 2H-benzo[f]chromene-2-thiones and 2H-benzo[f]chromen-2-ones, respectively, in high yields. The newly synthesized compounds were evaluated for antifungal and antibacterial activities. Among them, compounds (2-furyl)(3-thioxo-3H-benzo[f]chromen-2-yl)methanone and phenyl(3-oxo-3H-benzo[f]chromen-2-yl)methanone exhibited excellent antifungal activity against tested fungi Curvularia lunata and Fusarium moniliforme. The highest antibacterial activity against the tested bacteria Escherichia coli and Staphylococcus aureus was observed for (4-chlorophenyl)(3-oxo-3H-benzo[f]chromen-2-yl)methanone. The results of antimicrobial screening demonstrate that (2-furyl)(3-thioxo-3H-benzo[f]chromen-2-yl)methanone, phenyl(3-oxo-3H-benzo[f]chromen-2-yl)methanone, and (4-chlorophenyl)(3-oxo-3H-benzo[f]chromen-2-yl)methanone are promising as antimicrobial drugs.

Sobre autores

Irom Chanu

Department of Chemistry

Email: ok_mukherjee@yahoo.co.in
Índia, Canchipur, 795003

Laishram Devi

Department of Basic Science and Humanities

Email: ok_mukherjee@yahoo.co.in
Índia, Imphal, 795004

Nonibala Khumanthem

Department of Life Science

Email: ok_mukherjee@yahoo.co.in
Índia, Canchipur, 795003

N. Singh

Department of Life Science

Email: ok_mukherjee@yahoo.co.in
Índia, Canchipur, 795003

Dalip Kumar

Department of Chemistry

Email: ok_mukherjee@yahoo.co.in
Índia, Pilani, 333031

Okram Singh

Department of Chemistry

Autor responsável pela correspondência
Email: ok_mukherjee@yahoo.co.in
Índia, Canchipur, 795003

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