A synthetic fragment 60–70 of the receptor for advanced glycation end products exhibits a therapeutic effect in an animal model of Alzheimer’s disease
- Авторы: Koroev D.O.1, Volpina O.M.1, Volkova T.D.1, Kamynina A.V.1, Filatova M.P.1, Balasanyants S.M.1, Samokhin A.N.2, Bobkova N.V.2
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Учреждения:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Institute of Cell Biophysics
- Выпуск: Том 43, № 2 (2017)
- Страницы: 150-154
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228453
- DOI: https://doi.org/10.1134/S1068162017020066
- ID: 228453
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Аннотация
Six synthetic peptides overlapping a fragment 60–76 of the receptor for advanced glycation end products (RAGE) were studied on a protective effect on spatial memory of animals in the experimental model of Alzheimer’s disease. It was shown that only a peptide corresponding to the fragment 60–70 of RAGE exhibits a therapeutic activity. Intranasal administration of this peptide into bulbectomized mice, which develop neurodegenerative features of the Alzheimer type, completely protects animal memory. Thus, it was found that the N-terminal region (60–70) within the peptide sequence 60–76 of RAGE is responsible for the revealed protective effect. The synthetic peptide RAGE-(60–70) could be the basis for the development of a new drug for the treatment of Alzheimer’s disease.
Об авторах
D. Koroev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Автор, ответственный за переписку.
Email: koroevd@gmail.com
Россия, Moscow, 117997
O. Volpina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: koroevd@gmail.com
Россия, Moscow, 117997
T. Volkova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: koroevd@gmail.com
Россия, Moscow, 117997
A. Kamynina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: koroevd@gmail.com
Россия, Moscow, 117997
M. Filatova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: koroevd@gmail.com
Россия, Moscow, 117997
S. Balasanyants
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: koroevd@gmail.com
Россия, Moscow, 117997
A. Samokhin
Institute of Cell Biophysics
Email: koroevd@gmail.com
Россия, Pushchino, Moscow oblast, 142290
N. Bobkova
Institute of Cell Biophysics
Email: koroevd@gmail.com
Россия, Pushchino, Moscow oblast, 142290
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