A synthetic fragment 60–70 of the receptor for advanced glycation end products exhibits a therapeutic effect in an animal model of Alzheimer’s disease


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Six synthetic peptides overlapping a fragment 60–76 of the receptor for advanced glycation end products (RAGE) were studied on a protective effect on spatial memory of animals in the experimental model of Alzheimer’s disease. It was shown that only a peptide corresponding to the fragment 60–70 of RAGE exhibits a therapeutic activity. Intranasal administration of this peptide into bulbectomized mice, which develop neurodegenerative features of the Alzheimer type, completely protects animal memory. Thus, it was found that the N-terminal region (60–70) within the peptide sequence 60–76 of RAGE is responsible for the revealed protective effect. The synthetic peptide RAGE-(60–70) could be the basis for the development of a new drug for the treatment of Alzheimer’s disease.

作者简介

D. Koroev

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

编辑信件的主要联系方式.
Email: koroevd@gmail.com
俄罗斯联邦, Moscow, 117997

O. Volpina

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: koroevd@gmail.com
俄罗斯联邦, Moscow, 117997

T. Volkova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: koroevd@gmail.com
俄罗斯联邦, Moscow, 117997

A. Kamynina

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: koroevd@gmail.com
俄罗斯联邦, Moscow, 117997

M. Filatova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: koroevd@gmail.com
俄罗斯联邦, Moscow, 117997

S. Balasanyants

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: koroevd@gmail.com
俄罗斯联邦, Moscow, 117997

A. Samokhin

Institute of Cell Biophysics

Email: koroevd@gmail.com
俄罗斯联邦, Pushchino, Moscow oblast, 142290

N. Bobkova

Institute of Cell Biophysics

Email: koroevd@gmail.com
俄罗斯联邦, Pushchino, Moscow oblast, 142290

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