Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1
- Авторлар: Zakharenko A.L.1, Luzina O.A.2, Sokolov D.N.2, Zakharova O.D.1, Rakhmanova M.E.3, Chepanova A.A.4, Dyrkheeva N.S.1, Lavrik O.I.1,3,4, Salakhutdinov N.F.2,3
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Мекемелер:
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
- Novosibirsk State University
- Altai State University
- Шығарылым: Том 43, № 1 (2017)
- Беттер: 84-90
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228426
- DOI: https://doi.org/10.1134/S1068162017010125
- ID: 228426
Дәйексөз келтіру
Аннотация
The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells’ viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.
Авторлар туралы
A. Zakharenko
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Хат алмасуға жауапты Автор.
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090
O. Luzina
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090
D. Sokolov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090
O. Zakharova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090
M. Rakhmanova
Novosibirsk State University
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090
A. Chepanova
Altai State University
Email: sashaz@niboch.nsc.ru
Ресей, Barnaul, 656049
N. Dyrkheeva
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090
O. Lavrik
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch; Novosibirsk State University; Altai State University
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090; Barnaul, 656049
N. Salakhutdinov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
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