Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1


Дәйексөз келтіру

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Аннотация

The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells’ viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.

Авторлар туралы

A. Zakharenko

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch

Хат алмасуға жауапты Автор.
Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090

O. Luzina

Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch

Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090

D. Sokolov

Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch

Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090

O. Zakharova

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch

Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090

M. Rakhmanova

Novosibirsk State University

Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090

A. Chepanova

Altai State University

Email: sashaz@niboch.nsc.ru
Ресей, Barnaul, 656049

N. Dyrkheeva

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch

Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090

O. Lavrik

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch; Novosibirsk State University; Altai State University

Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090; Barnaul, 656049

N. Salakhutdinov

Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University

Email: sashaz@niboch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090

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© Pleiades Publishing, Ltd., 2017