Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids


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Resumo

Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of 66%. 3-Aminopropylphosphinic acid was prepared from allylamine in three steps with an overall yield of 56%. These improved protocols allowed to obtain these commercially unavailable phosphinic analogues of glutamic acid and GABA for testing on potential molecular targets.

Sobre autores

M. Khomutov

Engelhardt Institute of Molecular Biology

Email: alexkhom@list.ru
Rússia, ul. Vavilova 32, Moscow, 119991

A. Formanovsky

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: alexkhom@list.ru
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997

I. Mikhura

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: alexkhom@list.ru
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997

J. Vepsalainen

School of Pharmacy

Email: alexkhom@list.ru
Finlândia, Kuopio, FIN-70211

S. Kochetkov

Engelhardt Institute of Molecular Biology

Email: alexkhom@list.ru
Rússia, ul. Vavilova 32, Moscow, 119991

D. De Biase

Istituto Pasteur Italia–Fondazione Cenci Bolognetti, Department of Medico-Surgical Sciences and Biotechnologies

Autor responsável pela correspondência
Email: daniela.debiase@uniroma1.it
Itália, Corso della Repubblica 79, Latina, 04100

A. Khomutov

Engelhardt Institute of Molecular Biology

Autor responsável pela correspondência
Email: alexkhom@list.ru
Rússia, ul. Vavilova 32, Moscow, 119991

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