Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids


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Аннотация

Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of 66%. 3-Aminopropylphosphinic acid was prepared from allylamine in three steps with an overall yield of 56%. These improved protocols allowed to obtain these commercially unavailable phosphinic analogues of glutamic acid and GABA for testing on potential molecular targets.

Авторлар туралы

M. Khomutov

Engelhardt Institute of Molecular Biology

Email: alexkhom@list.ru
Ресей, ul. Vavilova 32, Moscow, 119991

A. Formanovsky

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: alexkhom@list.ru
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997

I. Mikhura

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: alexkhom@list.ru
Ресей, ul. Miklukho-Maklaya 16/10, Moscow, 117997

J. Vepsalainen

School of Pharmacy

Email: alexkhom@list.ru
Финляндия, Kuopio, FIN-70211

S. Kochetkov

Engelhardt Institute of Molecular Biology

Email: alexkhom@list.ru
Ресей, ul. Vavilova 32, Moscow, 119991

D. De Biase

Istituto Pasteur Italia–Fondazione Cenci Bolognetti, Department of Medico-Surgical Sciences and Biotechnologies

Хат алмасуға жауапты Автор.
Email: daniela.debiase@uniroma1.it
Италия, Corso della Repubblica 79, Latina, 04100

A. Khomutov

Engelhardt Institute of Molecular Biology

Хат алмасуға жауапты Автор.
Email: alexkhom@list.ru
Ресей, ul. Vavilova 32, Moscow, 119991

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