Synthesis of new 1-alkyl-, 1-benzyl-, and 1-aryloxyethyl-substituted 4,5-dichloroimidazoles and their antimicrobial, protistocidal, and fungistatic properties
- Authors: Kovalenko A.A.1, Divaeva L.N.1, Zubenko A.A.2, Morkovnik A.S.1, Drobin Y.G.2, Fetisov L.N.2, Bodryakov A.N.2, Dorofeenko A.I.1
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Affiliations:
- Institute of Organic and Physical Chemistry
- North-Caucasian Regional Scientific Research Veterinary Institute
- Issue: Vol 42, No 5 (2016)
- Pages: 551-559
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228151
- DOI: https://doi.org/10.1134/S1068162016040129
- ID: 228151
Cite item
Abstract
Previously unknown 1-alkyl-, 1-benzyl-, and 1-aryloxyethylderivatives of dichloroimidazoles and products of their structural transformation were synthesized from 4,5-dichloroimidazole or 2-methyl-4,5- dichloroimidazole using alkyl, benzyl or aryloxyethyl halides. These N-substituted compounds were shown to have a weak antibacterial activity against some pathogenic gram-positive and gram-negative bacteria (Staphylococcus aureus and Escherichia coli). At the same time, some of the obtained compounds demonstrated a significant protistocidal activity against Colpoda steinii, which can exceed in strength the activity of clinically used veterinary drug Baycox. Moreover, these compounds showed a pronounced fungistatic effect.
About the authors
A. A. Kovalenko
Institute of Organic and Physical Chemistry
Email: divaevaln@mail.ru
Russian Federation, pr. Stachky 194/2, Rostov-on-Don, 344090
L. N. Divaeva
Institute of Organic and Physical Chemistry
Author for correspondence.
Email: divaevaln@mail.ru
Russian Federation, pr. Stachky 194/2, Rostov-on-Don, 344090
A. A. Zubenko
North-Caucasian Regional Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
A. S. Morkovnik
Institute of Organic and Physical Chemistry
Email: divaevaln@mail.ru
Russian Federation, pr. Stachky 194/2, Rostov-on-Don, 344090
Y. G. Drobin
North-Caucasian Regional Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
L. N. Fetisov
North-Caucasian Regional Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
A. N. Bodryakov
North-Caucasian Regional Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
A. I. Dorofeenko
Institute of Organic and Physical Chemistry
Email: divaevaln@mail.ru
Russian Federation, pr. Stachky 194/2, Rostov-on-Don, 344090