Novel 3-pyridinecarbonitriles incorporating sulfonamide moieties as anti-breast cancer agents


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

A novel series of 3-pyridinecarbonitrile derivatives incorporating sulfonamide moieties and sulfonyl derivatives was synthesized using 2-chloro-6-methylnicotinonitrile as a strategic starting material. The structures of the synthesized compounds were elucidated on the basis of elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data. All the prepared compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF-7). Most of the compounds showed good to moderate activity, higher than that of the reference drug doxorubicin. Two compounds showed the same activity as doxorubicin, while three compounds exhibited remarkable activity.

About the authors

Mostafa M. Ghorab

Pharmacognosy Department, College of Pharmacy; Department of Drug Radiation Research

Author for correspondence.
Email: mmsghorab@yahoo.com
Saudi Arabia, Riyadh, 11451; Nasr City, Cairo, 113701

Mansour S. Alsaid

Pharmacognosy Department, College of Pharmacy

Email: mmsghorab@yahoo.com
Saudi Arabia, Riyadh, 11451

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2016 Pleiades Publishing, Ltd.