Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase
- Authors: Burmistrov V.V.1, Butov G.M.1, Karlov D.S.2,3, Palyulin V.A.2, Zefirov N.S.2, Morisseau C.4, Hammock B.D.4
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Affiliations:
- Volzhskii Polytechnical Institute (Branch)
- Department of Chemistry
- ISCALARE Laboratory
- Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center
- Issue: Vol 42, No 4 (2016)
- Pages: 404-414
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228020
- DOI: https://doi.org/10.1134/S1068162016030067
- ID: 228020
Cite item
Abstract
A series of target-oriented competitive inhibitors of human soluble epoxide hydrolase have been synthesized. The compounds retain the inhibitory properties at concentrations down to 4 nM. Based on the results of molecular modeling, it has been shown that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme.
Keywords
About the authors
V. V. Burmistrov
Volzhskii Polytechnical Institute (Branch)
Email: butov@volpi.ru
Russian Federation, ul. Engelsa 42a, Volzhskii, 404121
G. M. Butov
Volzhskii Polytechnical Institute (Branch)
Author for correspondence.
Email: butov@volpi.ru
Russian Federation, ul. Engelsa 42a, Volzhskii, 404121
D. S. Karlov
Department of Chemistry; ISCALARE Laboratory
Email: butov@volpi.ru
Russian Federation, Moscow, 119991; Dolgoprudnyi, Moscow oblast, 141701
V. A. Palyulin
Department of Chemistry
Email: butov@volpi.ru
Russian Federation, Moscow, 119991
N. S. Zefirov
Department of Chemistry
Email: butov@volpi.ru
Russian Federation, Moscow, 119991
C. Morisseau
Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center
Email: butov@volpi.ru
United States, Davis, CA, 95616
B. D. Hammock
Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center
Email: butov@volpi.ru
United States, Davis, CA, 95616