The arsenolysis reaction in the biotechnological method of synthesis of modified purine β-D-arabinonucleosides


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We found a unique property of E. coli purine nucleoside phosphorylases to selectively perform the arsenolysis reaction of ribonucleosides in their active site without affecting β-D-arabinonucleosides. In the synthesis of modified β-D-arabinonucleosides from the corresponding ribonucleosides, the catalytical amount of sodium arsenate in the transglycosylation reaction provided a 95 to 98% conversion rate. Such an approach was shown to simplify the composition of the reaction mixtures and facilitate the isolation of the target nucleosides, particularly, vidarabine, fludarabine, and nelarabine.

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I. Konstantinova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

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Email: kid1968@yandex.ru
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997

I. Fateev

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: kid1968@yandex.ru
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997

A. Miroshnikov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: kid1968@yandex.ru
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997

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