The arsenolysis reaction in the biotechnological method of synthesis of modified purine β-D-arabinonucleosides
- 作者: Konstantinova I.D.1, Fateev I.V.1, Miroshnikov A.I.1
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隶属关系:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- 期: 卷 42, 编号 4 (2016)
- 页面: 372-380
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228000
- DOI: https://doi.org/10.1134/S1068162016040105
- ID: 228000
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详细
We found a unique property of E. coli purine nucleoside phosphorylases to selectively perform the arsenolysis reaction of ribonucleosides in their active site without affecting β-D-arabinonucleosides. In the synthesis of modified β-D-arabinonucleosides from the corresponding ribonucleosides, the catalytical amount of sodium arsenate in the transglycosylation reaction provided a 95 to 98% conversion rate. Such an approach was shown to simplify the composition of the reaction mixtures and facilitate the isolation of the target nucleosides, particularly, vidarabine, fludarabine, and nelarabine.
作者简介
I. Konstantinova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
编辑信件的主要联系方式.
Email: kid1968@yandex.ru
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997
I. Fateev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: kid1968@yandex.ru
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997
A. Miroshnikov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: kid1968@yandex.ru
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997
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