The interaction of secreted proteins Noggin4 and Wnt8 from Xenopus laevis embryos
- Authors: Martynova N.Y.1, Nesterenko A.M.1, Orlov E.E.1, Eroshkin F.M.1, Borodulin A.V.1, Bayramov A.V.1, Zaraisky A.G.1
- 
							Affiliations: 
							- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
 
- Issue: Vol 42, No 3 (2016)
- Pages: 340-342
- Section: Letter to the Editor
- URL: https://journals.rcsi.science/1068-1620/article/view/227988
- DOI: https://doi.org/10.1134/S1068162016030110
- ID: 227988
Cite item
Abstract
We demonstrated that the secreted protein Noggin4 from Xenopus laevis was capable of the in vitro binding to the secreted factor Wnt8, one of the ligands of the Wnt/betaCatenin signaling pathway. It was also shown that posttranslational modifications occurring during secretion of these proteins from the embryonic cells were necessary for their effective interaction. Also, we proposed a method for the preparation of physiologically active secreted morphogenic proteins from the intercellular space of the Xenopus laevis embryos.
About the authors
N. Y. Martynova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
							Author for correspondence.
							Email: martnat61@yahoo.com
				                					                																			                												                	Russian Federation, 							Miklukho-Maklaya 16/10, Moscow, 117997						
A. M. Nesterenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
														Email: azaraisky@yahoo.com
				                					                																			                												                	Russian Federation, 							Miklukho-Maklaya 16/10, Moscow, 117997						
E. E. Orlov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
														Email: azaraisky@yahoo.com
				                					                																			                												                	Russian Federation, 							Miklukho-Maklaya 16/10, Moscow, 117997						
F. M. Eroshkin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
														Email: azaraisky@yahoo.com
				                					                																			                												                	Russian Federation, 							Miklukho-Maklaya 16/10, Moscow, 117997						
A. V. Borodulin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
														Email: azaraisky@yahoo.com
				                					                																			                												                	Russian Federation, 							Miklukho-Maklaya 16/10, Moscow, 117997						
A. V. Bayramov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
														Email: azaraisky@yahoo.com
				                					                																			                												                	Russian Federation, 							Miklukho-Maklaya 16/10, Moscow, 117997						
A. G. Zaraisky
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
							Author for correspondence.
							Email: azaraisky@yahoo.com
				                					                																			                												                	Russian Federation, 							Miklukho-Maklaya 16/10, Moscow, 117997						
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