Antioxidant and α-glucosidase inhibitory phenolic constituents of Lactuca indica L.
- Authors: Choi C.1, Eom H.J.2, Kim K.H.2
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Affiliations:
- College of Pharmacy
- School of Pharmacy
- Issue: Vol 42, No 3 (2016)
- Pages: 310-315
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227950
- DOI: https://doi.org/10.1134/S1068162016030079
- ID: 227950
Cite item
Abstract
Lactuca indica L. (Compositae) has been used as a folk medicine for the treatment of intestinal disorders. Phytochemical constituents of L. indica were investigated, and their antioxidant and α-glucosidase inhibitory activities thoroughly studied. A phytochemical investigation of the aerial parts of L. indica resulted in the isolation and identification of eight phenolic compounds. The structures of the compounds were elucidated on the basis of spectroscopic evidence as apigenin, luteolin, isoquercitrin, chlorogenic acid, protocatechuic acid, p-hydroxymethyl benzoic acid, trans-cinnamic acid, and p-coumaric acid. Luteolin, isoquercitrin, chlorogenic acid, and p-hydroxymethyl benzoic acid showed antioxidant activities with IC50 values in the range of 35.5–52.5 μM. In addition, apigenin and luteolin showed α-glucosidase inhibition activities with IC50 values of 96.4 and 100.7 μM, respectively. These findings strongly suggest that L. indica is a potential source of natural antioxidants and/or anti-diabetic agents in pharmaceutical and health functional foods.
About the authors
Chang-Ik Choi
College of Pharmacy
Email: khkim83@skku.edu
Korea, Republic of, Goyang, 410-820
Hee Jeong Eom
School of Pharmacy
Email: khkim83@skku.edu
Korea, Republic of, Suwon, 440-746
Ki Hyun Kim
School of Pharmacy
Author for correspondence.
Email: khkim83@skku.edu
Korea, Republic of, Suwon, 440-746