Anthelmintic and antibacterial screening of a new series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines
- Authors: Bhandari N.1, Gaonkar S.L.1
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Affiliations:
- Department of Chemistry, Manipal Institute of Technology
- Issue: Vol 42, No 2 (2016)
- Pages: 210-214
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227886
- DOI: https://doi.org/10.1134/S1068162016020096
- ID: 227886
Cite item
Abstract
A series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines was synthesized. Structural elucidation was accomplished by 1H NMR, 13C NMR, IR, and elemental analyses of synthesized compounds. The title compounds were derived from 4-(4-nitrophenoxy)phenyl thiourea, which is the key intermediate in the synthesis of nitroscanate, an anthelmintic drug. Among the synthesized compounds, N-[4-(4-nitrophenoxy)phenyl]-4-(4-fluorophenyl)-1,3-thiazol-2-amine and N-[4-(4-nitrophenoxy)phenyl]-4-(4-methoxyphenyl)-1,3-thiazol-2-amine exhibited potent anthelmintic and antibacterial activities.
About the authors
Namratha Bhandari
Department of Chemistry, Manipal Institute of Technology
Email: gankarslg@rediffmail.com
India, Manipal, 576104
Santosh L. Gaonkar
Department of Chemistry, Manipal Institute of Technology
Author for correspondence.
Email: gankarslg@rediffmail.com
India, Manipal, 576104