Acyl derivatives of ivermectin 5-oxime with antifungal activity

E. I. Chernoburova; M. A. Shchetinina; M. Kh. Dzhafarov; V. B. Krylov; I. V. Zavarzin

doi:10.1007/s11172-019-2405-7

Acyl derivatives of ivermectin 5-oxime with antifungal activity

作者: Chernoburova E.I.¹, Shchetinina M.A.¹, Dzhafarov M.K.¹, Krylov V.B.¹, Zavarzin I.V.¹
隶属关系:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
期: 卷 68, 编号 2 (2019)
页面: 438-444
栏目: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/243266
DOI: https://doi.org/10.1007/s11172-019-2405-7
ID: 243266

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详细

Acylation of ivermectin 5-oxime was first studied. Procedures for selective acylation of ivermectin 5-oxime either selectively at 5-oxime group or at both 5-oxime group and 4″-hydroxy group to give, respectively, mono- and diacyl derivatives were developed. The synthesized compounds exhibit antifungal activity.