Acyl derivatives of ivermectin 5-oxime with antifungal activity
- Authors: Chernoburova E.I.1, Shchetinina M.A.1, Dzhafarov M.K.1, Krylov V.B.1, Zavarzin I.V.1
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Affiliations:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Issue: Vol 68, No 2 (2019)
- Pages: 438-444
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243266
- DOI: https://doi.org/10.1007/s11172-019-2405-7
- ID: 243266
Cite item
Abstract
Acylation of ivermectin 5-oxime was first studied. Procedures for selective acylation of ivermectin 5-oxime either selectively at 5-oxime group or at both 5-oxime group and 4″-hydroxy group to give, respectively, mono- and diacyl derivatives were developed. The synthesized compounds exhibit antifungal activity.
About the authors
E. I. Chernoburova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
M. A. Shchetinina
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
M. Kh. Dzhafarov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
V. B. Krylov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
I. V. Zavarzin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991