Comparative reactivity of hydroxyketones and their derivatives in the reactions with N,S-nucleophiles

详细

The reactions of thiosemicarbazide (TSC), thiocarbohydrazide, and hydrazine thiocarbamate with oxyketones, haloketones, and derivatives of acetylenic alcohols were studied. Thiadiazines bearing exocyclic thio and hydrazo groups were synthesized. Acetylenic alcohols react with TSC to give the corresponding thiazolidines. The reactions of halo derivatives of acetylenic alcohols with TSC are complicated by side reactions.