Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin

M. A. Shchetinina; E. I. Chernoburova; N. G. Kolotyrkina; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

doi:10.1007/s11172-018-2146-z

Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin

作者: Shchetinina M.A.¹, Chernoburova E.I.¹, Kolotyrkina N.G.¹, Dzhafarov M.K.², Vasilevich F.I.², Zavarzin I.V.¹
隶属关系:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
2. K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
期: 卷 67, 编号 5 (2018)
页面: 836-839
栏目: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/242512
DOI: https://doi.org/10.1007/s11172-018-2146-z
ID: 242512

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Treatment of ivermectin with sulfuric acid–acetic anhydride in pyridine gives sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin. The synthesized salts are water-soluble compounds with promising antiparasitic activity.