Synthesis of substituted pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-ones and their sulfinyl and sulfonyl derivatives
- 作者: Kalugin V.1, Shestopalov A.1
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隶属关系:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- 期: 卷 66, 编号 3 (2017)
- 页面: 523-530
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240249
- DOI: https://doi.org/10.1007/s11172-017-1766-z
- ID: 240249
如何引用文章
详细
A method for the synthesis of previously unknown pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-ones was suggested, which includes a condensation reaction of substituted 3-cyanopyridine-2(1H)-thiones with methyl 2-(chloromethyl)benzoate and subsequent treatment of the condensation products with potassium tert-butoxide. The oxidation of the condensation products to sulfoxides or sulfones and subsequent treatment of these compounds with potassium tert-butoxide led to substituted pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-one 11-oxides or substituted pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-one 11,11-dioxides.
作者简介
V. Kalugin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: vek@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
A. Shestopalov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vek@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991