Synthesis of substituted pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-ones and their sulfinyl and sulfonyl derivatives
- Authors: Kalugin V.E.1, Shestopalov A.M.1
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Affiliations:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Issue: Vol 66, No 3 (2017)
- Pages: 523-530
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240249
- DOI: https://doi.org/10.1007/s11172-017-1766-z
- ID: 240249
Cite item
Abstract
A method for the synthesis of previously unknown pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-ones was suggested, which includes a condensation reaction of substituted 3-cyanopyridine-2(1H)-thiones with methyl 2-(chloromethyl)benzoate and subsequent treatment of the condensation products with potassium tert-butoxide. The oxidation of the condensation products to sulfoxides or sulfones and subsequent treatment of these compounds with potassium tert-butoxide led to substituted pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-one 11-oxides or substituted pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-one 11,11-dioxides.
About the authors
V. E. Kalugin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: vek@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
A. M. Shestopalov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vek@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991