Ways to enhance chemosensitizing of tumor cells with NO donors in tumor therapy with cytostatics and hydroxamic acids
- 作者: Bogatyrenko T.1, Kuropteva Z.2, Bayder L.2, Serkov I.3, Bogatyrenko V.1, Sashenkova T.1, Klimanova E.1, Mishchenko D.1, Konovalova N.1
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隶属关系:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- 期: 卷 65, 编号 10 (2016)
- 页面: 2509-2512
- 栏目: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/239254
- DOI: https://doi.org/10.1007/s11172-016-1615-5
- ID: 239254
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详细
The influence of an organic NO donor belonging to non-steroidal anti-inflammatory drugs (NSAIDs) — NO-indomethacin (NO-Ind) on the antitumor effect of cyclophosphamide (CP) and its compositions with asparagyl hydroxamic acid (AHA) were studied, along with the influence on the activity of cytochrome P-450. Compared to a previously studied NSAID — diclofenac hydroxamic acid nitrate — NO-Ind exhibited lower enhancement of CP activity even when hydroxamic acid was added to the drug composition. EPR spectroscopy was used to evaluate the changes in activity of P-450 under the action of modified NSAIDs. The studies demonstrated partial inhibition of cytochrome P-450, the inhibition time is being greater for the first NSAID than for NO-Ind. The duration of P-450 inhibition under the action of different NO donors influences activity of CP.
作者简介
T. Bogatyrenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
Z. Kuropteva
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 4 ul. Kosygina, Moscow, 119991
L. Bayder
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 4 ul. Kosygina, Moscow, 119991
I. Serkov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
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俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
V. Bogatyrenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
T. Sashenkova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
E. Klimanova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
D. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
N. Konovalova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
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俄罗斯联邦, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432