Ways to enhance chemosensitizing of tumor cells with NO donors in tumor therapy with cytostatics and hydroxamic acids
- Autores: Bogatyrenko T.1, Kuropteva Z.2, Bayder L.2, Serkov I.3, Bogatyrenko V.1, Sashenkova T.1, Klimanova E.1, Mishchenko D.1, Konovalova N.1
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Afiliações:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Edição: Volume 65, Nº 10 (2016)
- Páginas: 2509-2512
- Seção: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/239254
- DOI: https://doi.org/10.1007/s11172-016-1615-5
- ID: 239254
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Resumo
The influence of an organic NO donor belonging to non-steroidal anti-inflammatory drugs (NSAIDs) — NO-indomethacin (NO-Ind) on the antitumor effect of cyclophosphamide (CP) and its compositions with asparagyl hydroxamic acid (AHA) were studied, along with the influence on the activity of cytochrome P-450. Compared to a previously studied NSAID — diclofenac hydroxamic acid nitrate — NO-Ind exhibited lower enhancement of CP activity even when hydroxamic acid was added to the drug composition. EPR spectroscopy was used to evaluate the changes in activity of P-450 under the action of modified NSAIDs. The studies demonstrated partial inhibition of cytochrome P-450, the inhibition time is being greater for the first NSAID than for NO-Ind. The duration of P-450 inhibition under the action of different NO donors influences activity of CP.
Sobre autores
T. Bogatyrenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: btn@icp.ac.ru
Rússia, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
Z. Kuropteva
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: btn@icp.ac.ru
Rússia, 4 ul. Kosygina, Moscow, 119991
L. Bayder
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: btn@icp.ac.ru
Rússia, 4 ul. Kosygina, Moscow, 119991
I. Serkov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
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Rússia, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
V. Bogatyrenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: btn@icp.ac.ru
Rússia, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
T. Sashenkova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: btn@icp.ac.ru
Rússia, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
E. Klimanova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: btn@icp.ac.ru
Rússia, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
D. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: btn@icp.ac.ru
Rússia, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
N. Konovalova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: btn@icp.ac.ru
Rússia, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432