Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[ b ]oxepine derivatives of colchicine

S. Yu. Bukhvalova; A. A. Maleev; Yu. A. Gracheva; Yu. V. Voitovich; S. K. Ignatov; E. V. Svirshchevskaya; A. Yu. Fedorov

doi:10.1007/s11172-019-2689-7

Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine

Авторы: Bukhvalova S.¹^,2, Maleev A.², Gracheva Y.², Voitovich Y.², Ignatov S.², Svirshchevskaya E.³, Fedorov A.²
Учреждения:
1. G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences
2. N. I. Lobachevsky State University of Nizhny Novgorod
3. M. M. Shemyakin—Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Выпуск: Том 68, № 12 (2019)
Страницы: 2205-2215
Раздел: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/243550
DOI: https://doi.org/10.1007/s11172-019-2689-7
ID: 243550

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Аннотация
Об авторах
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Аннотация

New allocolchicine derivatives bearing 2,3-dihydrobenzo[b]oxepine moiety were synthesized via gold-catalyzed cyclization as a key synthetic step. The obtained 2,3-dihydrobenzo[b]oxepine-containing allocolchicinoids possess cytotoxic activity against HEK293, PANC-1, COL0357, HeLa, and Colon26 cancer cell lines at low micromolar range of concentrations.

Ключевые слова

antitumor agents, colchicine, tubulin, benzo [b] oxepines, gold-catalyzed cyclization

Об авторах

S. Bukhvalova

G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences; N. I. Lobachevsky State University of Nizhny Novgorod

Email: afedorovnn@yandex.ru
Россия, 49 ul. Tropinina, Nizhny Novgorod, 603137; 23 prosp. Gagarina, Nizhny Novgorod, 603950