Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[ b ]oxepine derivatives of colchicine

S. Yu. Bukhvalova; A. A. Maleev; Yu. A. Gracheva; Yu. V. Voitovich; S. K. Ignatov; E. V. Svirshchevskaya; A. Yu. Fedorov

doi:10.1007/s11172-019-2689-7

Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine

Авторлар: Bukhvalova S.¹^,2, Maleev A.², Gracheva Y.², Voitovich Y.², Ignatov S.², Svirshchevskaya E.³, Fedorov A.²
Мекемелер:
1. G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences
2. N. I. Lobachevsky State University of Nizhny Novgorod
3. M. M. Shemyakin—Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Шығарылым: Том 68, № 12 (2019)
Беттер: 2205-2215
Бөлім: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/243550
DOI: https://doi.org/10.1007/s11172-019-2689-7
ID: 243550

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Аннотация

New allocolchicine derivatives bearing 2,3-dihydrobenzo[b]oxepine moiety were synthesized via gold-catalyzed cyclization as a key synthetic step. The obtained 2,3-dihydrobenzo[b]oxepine-containing allocolchicinoids possess cytotoxic activity against HEK293, PANC-1, COL0357, HeLa, and Colon26 cancer cell lines at low micromolar range of concentrations.

Негізгі сөздер

antitumor agents, colchicine, tubulin, benzo [b] oxepines, gold-catalyzed cyclization

Авторлар туралы

S. Bukhvalova

G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences; N. I. Lobachevsky State University of Nizhny Novgorod

Email: afedorovnn@yandex.ru
Ресей, 49 ul. Tropinina, Nizhny Novgorod, 603137; 23 prosp. Gagarina, Nizhny Novgorod, 603950