Efficient hydrogenation of benzaldoximes and Schiff bases on ceramic high-porosity palladium catalysts
- Авторы: Ignatov A.1, Varakutin A.2, Solov’eva I.2, Karmanova I.1, Kozlov I.3, Semenova M.4, Semenov V.1
-
Учреждения:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- NOATEQ Ltd., Building 10
- N. K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences
- Выпуск: Том 67, № 8 (2018)
- Страницы: 1394-1400
- Раздел: Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242797
- DOI: https://doi.org/10.1007/s11172-018-2230-4
- ID: 242797
Цитировать
Аннотация
An efficient catalytic method for the synthesis of benzyl- and dibenzylamines by hydrogenating oximes and Schiffbases was developed on palladium supported high-porosity foamed ceramic block catalyst. The multiple regeneration ability of the foamed ceramic block catalyst can significantly decrease the Pd consumption as compared to the use of the conventional 10%Pd/C catalyst. Owing to a high hardness of the foamed ceramic catalyst, the reaction mixture can rapidly be removed from the reactor without using filtering devices. The structures produced by the reaction are fragments of biologically active and natural molecules. Antiproliferative properties of dibenzylamines revealed on the sea urchin embryo model suggest that these compounds can be considered as promising agents for the design of new anticancer drugs.
Об авторах
A. Ignatov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vs@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
A. Varakutin
D. I. Mendeleev University of Chemical Technology of Russia
Email: vs@ioc.ac.ru
Россия, 9 Miusskaya pl., Moscow, 125047
I. Solov’eva
D. I. Mendeleev University of Chemical Technology of Russia
Email: vs@ioc.ac.ru
Россия, 9 Miusskaya pl., Moscow, 125047
I. Karmanova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vs@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
I. Kozlov
NOATEQ Ltd., Building 10
Email: vs@ioc.ac.ru
Россия, 5 ul. Gabrichevskogo, Moscow, 125367
M. Semenova
N. K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences
Email: vs@ioc.ac.ru
Россия, 26 ul. Vavilova, Moscow, 119334
V. Semenov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: vs@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991