Efficient hydrogenation of benzaldoximes and Schiff bases on ceramic high-porosity palladium catalysts
- Authors: Ignatov A.V.1, Varakutin A.E.2, Solov’eva I.N.2, Karmanova I.B.1, Kozlov I.A.3, Semenova M.N.4, Semenov V.V.1
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Affiliations:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- NOATEQ Ltd., Building 10
- N. K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences
- Issue: Vol 67, No 8 (2018)
- Pages: 1394-1400
- Section: Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242797
- DOI: https://doi.org/10.1007/s11172-018-2230-4
- ID: 242797
Cite item
Abstract
An efficient catalytic method for the synthesis of benzyl- and dibenzylamines by hydrogenating oximes and Schiffbases was developed on palladium supported high-porosity foamed ceramic block catalyst. The multiple regeneration ability of the foamed ceramic block catalyst can significantly decrease the Pd consumption as compared to the use of the conventional 10%Pd/C catalyst. Owing to a high hardness of the foamed ceramic catalyst, the reaction mixture can rapidly be removed from the reactor without using filtering devices. The structures produced by the reaction are fragments of biologically active and natural molecules. Antiproliferative properties of dibenzylamines revealed on the sea urchin embryo model suggest that these compounds can be considered as promising agents for the design of new anticancer drugs.
About the authors
A. V. Ignatov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vs@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
A. E. Varakutin
D. I. Mendeleev University of Chemical Technology of Russia
Email: vs@ioc.ac.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
I. N. Solov’eva
D. I. Mendeleev University of Chemical Technology of Russia
Email: vs@ioc.ac.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
I. B. Karmanova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vs@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
I. A. Kozlov
NOATEQ Ltd., Building 10
Email: vs@ioc.ac.ru
Russian Federation, 5 ul. Gabrichevskogo, Moscow, 125367
M. N. Semenova
N. K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences
Email: vs@ioc.ac.ru
Russian Federation, 26 ul. Vavilova, Moscow, 119334
V. V. Semenov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: vs@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991