Efficient hydrogenation of benzaldoximes and Schiff bases on ceramic high-porosity palladium catalysts


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An efficient catalytic method for the synthesis of benzyl- and dibenzylamines by hydrogenating oximes and Schiffbases was developed on palladium supported high-porosity foamed ceramic block catalyst. The multiple regeneration ability of the foamed ceramic block catalyst can significantly decrease the Pd consumption as compared to the use of the conventional 10%Pd/C catalyst. Owing to a high hardness of the foamed ceramic catalyst, the reaction mixture can rapidly be removed from the reactor without using filtering devices. The structures produced by the reaction are fragments of biologically active and natural molecules. Antiproliferative properties of dibenzylamines revealed on the sea urchin embryo model suggest that these compounds can be considered as promising agents for the design of new anticancer drugs.

作者简介

A. Ignatov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: vs@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991

A. Varakutin

D. I. Mendeleev University of Chemical Technology of Russia

Email: vs@ioc.ac.ru
俄罗斯联邦, 9 Miusskaya pl., Moscow, 125047

I. Solov’eva

D. I. Mendeleev University of Chemical Technology of Russia

Email: vs@ioc.ac.ru
俄罗斯联邦, 9 Miusskaya pl., Moscow, 125047

I. Karmanova

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: vs@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991

I. Kozlov

NOATEQ Ltd., Building 10

Email: vs@ioc.ac.ru
俄罗斯联邦, 5 ul. Gabrichevskogo, Moscow, 125367

M. Semenova

N. K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences

Email: vs@ioc.ac.ru
俄罗斯联邦, 26 ul. Vavilova, Moscow, 119334

V. Semenov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: vs@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991

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