3-Pyridylisoxazoles as prototypes of antiaggregatory agents
- Авторы: Demina O.1, Belikov N.1, Varfolomeev S.1, Khodonov A.1
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Учреждения:
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Выпуск: Том 67, № 5 (2018)
- Страницы: 866-877
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242528
- DOI: https://doi.org/10.1007/s11172-018-2151-2
- ID: 242528
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Аннотация
A series of 5-alkyl-3-pyridylisoxazoles was synthesized using the 3-(3-pyridyl)isoxazole scaff old. All compounds of the series possessed antiaggregatory activity in the concentration range of 6•10–6–6•10–4 mol L–1. Analysis of the experimental data on the antiaggregatory activity revealed the presence of spatial constraints for the alkyl substituents in position 5 of the isoxazole ring. 5-Alkyl-3-(3-pyridyl)isoxazoles are rather selective for platelet membrane receptors.
Об авторах
O. Demina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: ovd@sky.chph.ras.ru
Россия, 4 ul. Kosigina, Moscow, 119334
N. Belikov
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ovd@sky.chph.ras.ru
Россия, 4 ul. Kosigina, Moscow, 119334
S. Varfolomeev
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ovd@sky.chph.ras.ru
Россия, 4 ul. Kosigina, Moscow, 119334
A. Khodonov
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ovd@sky.chph.ras.ru
Россия, 4 ul. Kosigina, Moscow, 119334