3-Pyridylisoxazoles as prototypes of antiaggregatory agents

O. V. Demina; N. E. Belikov; S. D. Varfolomeev; A. A. Khodonov

doi:10.1007/s11172-018-2151-2

3-Pyridylisoxazoles as prototypes of antiaggregatory agents

Authors: Demina O.V.¹, Belikov N.E.¹, Varfolomeev S.D.¹, Khodonov A.A.¹
Affiliations:
1. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Issue: Vol 67, No 5 (2018)
Pages: 866-877
Section: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/242528
DOI: https://doi.org/10.1007/s11172-018-2151-2
ID: 242528

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Abstract

A series of 5-alkyl-3-pyridylisoxazoles was synthesized using the 3-(3-pyridyl)isoxazole scaff old. All compounds of the series possessed antiaggregatory activity in the concentration range of 6•10^–6–6•10^–4 mol L^–1. Analysis of the experimental data on the antiaggregatory activity revealed the presence of spatial constraints for the alkyl substituents in position 5 of the isoxazole ring. 5-Alkyl-3-(3-pyridyl)isoxazoles are rather selective for platelet membrane receptors.