3-Pyridylisoxazoles as prototypes of antiaggregatory agents
- Authors: Demina O.V.1, Belikov N.E.1, Varfolomeev S.D.1, Khodonov A.A.1
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Affiliations:
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 67, No 5 (2018)
- Pages: 866-877
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242528
- DOI: https://doi.org/10.1007/s11172-018-2151-2
- ID: 242528
Cite item
Abstract
A series of 5-alkyl-3-pyridylisoxazoles was synthesized using the 3-(3-pyridyl)isoxazole scaff old. All compounds of the series possessed antiaggregatory activity in the concentration range of 6•10–6–6•10–4 mol L–1. Analysis of the experimental data on the antiaggregatory activity revealed the presence of spatial constraints for the alkyl substituents in position 5 of the isoxazole ring. 5-Alkyl-3-(3-pyridyl)isoxazoles are rather selective for platelet membrane receptors.
About the authors
O. V. Demina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: ovd@sky.chph.ras.ru
Russian Federation, 4 ul. Kosigina, Moscow, 119334
N. E. Belikov
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ovd@sky.chph.ras.ru
Russian Federation, 4 ul. Kosigina, Moscow, 119334
S. D. Varfolomeev
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ovd@sky.chph.ras.ru
Russian Federation, 4 ul. Kosigina, Moscow, 119334
A. A. Khodonov
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ovd@sky.chph.ras.ru
Russian Federation, 4 ul. Kosigina, Moscow, 119334