Modification of biologically active amides and amines with fluorine-containing heterocycles 12.* Endo- and exocyclic modifications of the drug riluzole with trifluoromethyl-containing heterocycles
- Авторы: Sokolov V.1, Aksinenko A.1, Sokolov A.1, Gabrelian A.1, Efimova A.1, Grigoriev V.1
-
Учреждения:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Выпуск: Том 66, № 1 (2017)
- Страницы: 99-103
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239840
- DOI: https://doi.org/10.1007/s11172-017-1706-y
- ID: 239840
Цитировать
Аннотация
New derivatives of the drug riluzole, 6-(trifluoromethoxy)benzothiazol-2-ylamine, modified at the endo- and exocyclic nitrogen atoms with trifluoromethyl-containing heterocycles were synthesized via transformations of methyltrifluoropyruvate and hexafluoroacetone N-6-(trifluoromethoxy)benzothiazol-2-ylimines by meams of cycloaddition and cyclocondensation reactions, respectively. The influence of the resulting compounds on neuronal NMDA receptors, as well as on the release and reuptake of the neurotransmitter glutamate was investigated.
Об авторах
V. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: alaks@ipac.ac.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Aksinenko
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Gabrelian
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Efimova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
V. Grigoriev
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432