Modification of biologically active amides and amines with fluorine-containing heterocycles 12.* Endo- and exocyclic modifications of the drug riluzole with trifluoromethyl-containing heterocycles
- Authors: Sokolov V.B.1, Aksinenko A.Y.1, Sokolov A.V.1, Gabrelian A.1, Efimova A.D.1, Grigoriev V.V.1
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Affiliations:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Issue: Vol 66, No 1 (2017)
- Pages: 99-103
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239840
- DOI: https://doi.org/10.1007/s11172-017-1706-y
- ID: 239840
Cite item
Abstract
New derivatives of the drug riluzole, 6-(trifluoromethoxy)benzothiazol-2-ylamine, modified at the endo- and exocyclic nitrogen atoms with trifluoromethyl-containing heterocycles were synthesized via transformations of methyltrifluoropyruvate and hexafluoroacetone N-6-(trifluoromethoxy)benzothiazol-2-ylimines by meams of cycloaddition and cyclocondensation reactions, respectively. The influence of the resulting compounds on neuronal NMDA receptors, as well as on the release and reuptake of the neurotransmitter glutamate was investigated.
About the authors
V. B. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. V. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Gabrelian
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. D. Efimova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
V. V. Grigoriev
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432