Cobaltocenium acetylsalicylate: synthesis and circular dichroism study of interactions with DNA

Resumo

Cobaltocenium acetylsalicylate was synthesized and characterized for the first time. The concentration dependences observed in its interaction with the double helix of DNA have been studied by circular dichroism. In these spectra, changes in the positions and decrease in the intensities of the curves in the positive and negative regions are observed when adding in increasing concentrations of cobaltocenium acetylsalicylate to calf thymus DNA. The observed changes in the effects of Cotton were interpreted as local changes in the conformation of the DNA double helix caused by the interaction of positively charged metallocenium cations with phosphate DNA fragments.