Email this article Cobaltocenium acetylsalicylate: synthesis and circular dichroism study of interactions with DNA
- Authors: Snegur L.V.1, Kaverin M.V.2, Babievsky K.K.1
-
Affiliations:
- A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 68, No 9 (2019)
- Pages: 1787-1790
- Section: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/243486
- DOI: https://doi.org/10.1007/s11172-019-2625-x
- ID: 243486
Cite item
Open Access
Access granted
Subscription Access
Abstract
Cobaltocenium acetylsalicylate was synthesized and characterized for the first time. The concentration dependences observed in its interaction with the double helix of DNA have been studied by circular dichroism. In these spectra, changes in the positions and decrease in the intensities of the curves in the positive and negative regions are observed when adding in increasing concentrations of cobaltocenium acetylsalicylate to calf thymus DNA. The observed changes in the effects of Cotton were interpreted as local changes in the conformation of the DNA double helix caused by the interaction of positively charged metallocenium cations with phosphate DNA fragments.
About the authors
L. V. Snegur
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Author for correspondence.
Email: snegur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
M. V. Kaverin
D. I. Mendeleev University of Chemical Technology of Russia
Email: snegur@ineos.ac.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
K. K. Babievsky
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
