Enviar artigo por via de e-mail Design, synthesis and evaluation of the antioxidant and neuroprotective properties of alkyl- and terpenylphenolchlorin conjugates
- Autores: Chukicheva I.Y.1, Buravlev E.V.1, Belykh D.V.1, Khudyaeva I.S.1, Fedorova I.V.1, Shevchenko O.G.2, Maximova M.A.3, Zainullina L.F.3,4, Vakhitova Y.V.3,4, Kutchin A.V.1
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Afiliações:
- Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
- Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
- Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences
- V. V. Zakusov Institute of Pharmacology
- Edição: Volume 67, Nº 3 (2018)
- Páginas: 548-557
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242384
- DOI: https://doi.org/10.1007/s11172-018-2109-4
- ID: 242384
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Resumo
The new amide conjugates were synthesized from methyl pheophorbide a and its carboxyl derivatives by reactions with aminomethyl derivatives of 2,4-dimethylphenol, 2-isocamphyl-4- methylphenol, 2-bornyl-4-methylphenol, and 2-isobornyl-4-methylphenol. The antioxidant activity of some conjugates was established by investigation of their ability to inhibit the accumulation of secondary products of lipid peroxidation in a brain of laboratory mice in vitro. The neuroprotective properties of porphyrin and terpenylphenol conjugates have been studied on the model of H2O2-induced oxidative stress in SH-SY5Y cells (neuroblastoma).
Sobre autores
I. Chukicheva
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
E. Buravlev
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
D. Belykh
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Khudyaeva
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Fedorova
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
O. Shevchenko
Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
M. Maximova
Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 71 prosp. Oktyabrya, Ufa, 450054
L. Zainullina
Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences; V. V. Zakusov Institute of Pharmacology
Email: chukichevaiy@mail.ru
Rússia, 71 prosp. Oktyabrya, Ufa, 450054; 8 ul. Baltiyskaya, Moscow, 125315
Yu. Vakhitova
Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences; V. V. Zakusov Institute of Pharmacology
Email: chukichevaiy@mail.ru
Rússia, 71 prosp. Oktyabrya, Ufa, 450054; 8 ul. Baltiyskaya, Moscow, 125315
A. Kutchin
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
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