Email this article Design, synthesis and evaluation of the antioxidant and neuroprotective properties of alkyl- and terpenylphenolchlorin conjugates
- Authors: Chukicheva I.Y.1, Buravlev E.V.1, Belykh D.V.1, Khudyaeva I.S.1, Fedorova I.V.1, Shevchenko O.G.2, Maximova M.A.3, Zainullina L.F.3,4, Vakhitova Y.V.3,4, Kutchin A.V.1
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Affiliations:
- Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
- Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
- Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences
- V. V. Zakusov Institute of Pharmacology
- Issue: Vol 67, No 3 (2018)
- Pages: 548-557
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242384
- DOI: https://doi.org/10.1007/s11172-018-2109-4
- ID: 242384
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Abstract
The new amide conjugates were synthesized from methyl pheophorbide a and its carboxyl derivatives by reactions with aminomethyl derivatives of 2,4-dimethylphenol, 2-isocamphyl-4- methylphenol, 2-bornyl-4-methylphenol, and 2-isobornyl-4-methylphenol. The antioxidant activity of some conjugates was established by investigation of their ability to inhibit the accumulation of secondary products of lipid peroxidation in a brain of laboratory mice in vitro. The neuroprotective properties of porphyrin and terpenylphenol conjugates have been studied on the model of H2O2-induced oxidative stress in SH-SY5Y cells (neuroblastoma).
About the authors
I. Yu. Chukicheva
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
E. V. Buravlev
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
D. V. Belykh
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. S. Khudyaeva
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. V. Fedorova
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
O. G. Shevchenko
Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
M. A. Maximova
Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 71 prosp. Oktyabrya, Ufa, 450054
L. F. Zainullina
Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences; V. V. Zakusov Institute of Pharmacology
Email: chukichevaiy@mail.ru
Russian Federation, 71 prosp. Oktyabrya, Ufa, 450054; 8 ul. Baltiyskaya, Moscow, 125315
Yu. V. Vakhitova
Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences; V. V. Zakusov Institute of Pharmacology
Email: chukichevaiy@mail.ru
Russian Federation, 71 prosp. Oktyabrya, Ufa, 450054; 8 ul. Baltiyskaya, Moscow, 125315
A. V. Kutchin
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
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