Amination of chloro-substituted heteroarenes with adamantane-containing amines
- Autores: Abel A.1, Grigorova O.1, Averin A.1, Maloshitskaya O.1, Butov G.2, Savelyev E.3, Orlinson B.3, Novakov I.3, Beletskaya I.1
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Afiliações:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
- Volgograd State Technical University
- Edição: Volume 65, Nº 7 (2016)
- Páginas: 1820-1828
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/238602
- DOI: https://doi.org/10.1007/s11172-016-1516-7
- ID: 238602
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Resumo
Amination of 3,6-dichloropyridazine, chloropyrazine, 2,3and 2,6-dichloropyrazines, 2-chloroquinoxaline, 1-chloroand 1,3-dichloroisoquinolines with various adamantane-containing amines characterized by different steric hindrances at the amino group was studied. The yields of the amination products depended on the structure of starting compounds. In the reactions of all the dichloroheteroarenes, selective substitution of only one chlorine atom took place, with the best yields being observed for 2,6-dichloropyrazine. In the reaction of 1,3-dichloroisoquinoline, the chlorine atom at position 1 was selectively substituted in up to 90% yield.
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Sobre autores
A. Abel
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
Rússia, Build. 3, 1 Leninskie Gory, Moscow, 119991
O. Grigorova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
Rússia, Build. 3, 1 Leninskie Gory, Moscow, 119991
A. Averin
Department of Chemistry, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: averin@org.chem.msu.ru
Rússia, Build. 3, 1 Leninskie Gory, Moscow, 119991
O. Maloshitskaya
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
Rússia, Build. 3, 1 Leninskie Gory, Moscow, 119991
G. Butov
Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
Email: averin@org.chem.msu.ru
Rússia, 42a ul. Engel’sa, Volzhsky, Volgograd Region, 404121
E. Savelyev
Volgograd State Technical University
Email: averin@org.chem.msu.ru
Rússia, 28 prosp. Lenina, Volgograd, 400131
B. Orlinson
Volgograd State Technical University
Email: averin@org.chem.msu.ru
Rússia, 28 prosp. Lenina, Volgograd, 400131
I. Novakov
Volgograd State Technical University
Email: averin@org.chem.msu.ru
Rússia, 28 prosp. Lenina, Volgograd, 400131
I. Beletskaya
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
Rússia, Build. 3, 1 Leninskie Gory, Moscow, 119991