Amination of chloro-substituted heteroarenes with adamantane-containing amines
- 作者: Abel A.1, Grigorova O.1, Averin A.1, Maloshitskaya O.1, Butov G.2, Savelyev E.3, Orlinson B.3, Novakov I.3, Beletskaya I.1
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隶属关系:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
- Volgograd State Technical University
- 期: 卷 65, 编号 7 (2016)
- 页面: 1820-1828
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/238602
- DOI: https://doi.org/10.1007/s11172-016-1516-7
- ID: 238602
如何引用文章
详细
Amination of 3,6-dichloropyridazine, chloropyrazine, 2,3and 2,6-dichloropyrazines, 2-chloroquinoxaline, 1-chloroand 1,3-dichloroisoquinolines with various adamantane-containing amines characterized by different steric hindrances at the amino group was studied. The yields of the amination products depended on the structure of starting compounds. In the reactions of all the dichloroheteroarenes, selective substitution of only one chlorine atom took place, with the best yields being observed for 2,6-dichloropyrazine. In the reaction of 1,3-dichloroisoquinoline, the chlorine atom at position 1 was selectively substituted in up to 90% yield.
作者简介
A. Abel
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991
O. Grigorova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991
A. Averin
Department of Chemistry, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: averin@org.chem.msu.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991
O. Maloshitskaya
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991
G. Butov
Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
Email: averin@org.chem.msu.ru
俄罗斯联邦, 42a ul. Engel’sa, Volzhsky, Volgograd Region, 404121
E. Savelyev
Volgograd State Technical University
Email: averin@org.chem.msu.ru
俄罗斯联邦, 28 prosp. Lenina, Volgograd, 400131
B. Orlinson
Volgograd State Technical University
Email: averin@org.chem.msu.ru
俄罗斯联邦, 28 prosp. Lenina, Volgograd, 400131
I. Novakov
Volgograd State Technical University
Email: averin@org.chem.msu.ru
俄罗斯联邦, 28 prosp. Lenina, Volgograd, 400131
I. Beletskaya
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: averin@org.chem.msu.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991