Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
- Авторлар: Tereshchenko O.1, Nikolskaya E.1, Zhunina O.1, Zavarzina V.2, Yabbarov N.1, Fomicheva M.1, Zubkov E.1,3, Sokol M.1, Gukasova N.2, Severin E.1
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Мекемелер:
- Russian Research Center for Molecular Diagnostics and Therapy
- National Research Center “Kurchatov Institute”
- Sechenov University, Ministry of Health of the Russian Federation
- Шығарылым: Том 67, № 12 (2018)
- Беттер: 2290-2296
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243233
- DOI: https://doi.org/10.1007/s11172-018-2372-4
- ID: 243233
Дәйексөз келтіру
Аннотация
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.
Авторлар туралы
O. Tereshchenko
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638
E. Nikolskaya
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638
O. Zhunina
Russian Research Center for Molecular Diagnostics and Therapy
Хат алмасуға жауапты Автор.
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638
V. Zavarzina
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Ресей, 1 pl. Akad. Kurchatova, Moscow, 123098
N. Yabbarov
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638
M. Fomicheva
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638
E. Zubkov
Russian Research Center for Molecular Diagnostics and Therapy; Sechenov University, Ministry of Health of the Russian Federation
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638; 2 Build., 8 ul. Trubetskaya, Moscow, 119991
M. Sokol
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638
N. Gukasova
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Ресей, 1 pl. Akad. Kurchatova, Moscow, 123098
E. Severin
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Ресей, 8 Simferopol´skii b-r, Moscow, 117638