Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
- 作者: Tereshchenko O.1, Nikolskaya E.1, Zhunina O.1, Zavarzina V.2, Yabbarov N.1, Fomicheva M.1, Zubkov E.1,3, Sokol M.1, Gukasova N.2, Severin E.1
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隶属关系:
- Russian Research Center for Molecular Diagnostics and Therapy
- National Research Center “Kurchatov Institute”
- Sechenov University, Ministry of Health of the Russian Federation
- 期: 卷 67, 编号 12 (2018)
- 页面: 2290-2296
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243233
- DOI: https://doi.org/10.1007/s11172-018-2372-4
- ID: 243233
如何引用文章
详细
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.
作者简介
O. Tereshchenko
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638
E. Nikolskaya
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638
O. Zhunina
Russian Research Center for Molecular Diagnostics and Therapy
编辑信件的主要联系方式.
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638
V. Zavarzina
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
俄罗斯联邦, 1 pl. Akad. Kurchatova, Moscow, 123098
N. Yabbarov
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638
M. Fomicheva
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638
E. Zubkov
Russian Research Center for Molecular Diagnostics and Therapy; Sechenov University, Ministry of Health of the Russian Federation
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638; 2 Build., 8 ul. Trubetskaya, Moscow, 119991
M. Sokol
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638
N. Gukasova
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
俄罗斯联邦, 1 pl. Akad. Kurchatova, Moscow, 123098
E. Severin
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
俄罗斯联邦, 8 Simferopol´skii b-r, Moscow, 117638