Synthesis and biological activity of 5-vinyl- and 5-allyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles
- Авторлар: Sokolov V.1, Aksinenko A.1, Epishina T.1, Goreva T.1, Shevtsova E.1, Dubova L.1, Shevtsov P.1, Rudakova E.1, Kovaleva N.1, Makhaeva G.1, Bachurin S.1
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Мекемелер:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Шығарылым: Том 67, № 11 (2018)
- Беттер: 2103-2107
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243193
- DOI: https://doi.org/10.1007/s11172-018-2335-9
- ID: 243193
Дәйексөз келтіру
Аннотация
A synthetic approach to the vinylation and allylation of tetrahydro-γ-carbolines with alkane dimethyl sulfonates in the presence of sodium hydride was developed. The effect of the synthesized 5-vinyl- and 5-allyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles on acetylcholinesterase, butyrylcholinesterase, and carboxylesterase activity, mitochondrial functions, and tubulin polymerization was investigated, and their antioxidant activity was evaluated.
Авторлар туралы
V. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
A. Aksinenko
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
T. Epishina
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
T. Goreva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
E. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
L. Dubova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
P. Shevtsov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
E. Rudakova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
N. Kovaleva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
G. Makhaeva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
S. Bachurin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432