Enviar artigo por via de e-mail Synthesis and biological activity of 5-vinyl- and 5-allyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles
- Autores: Sokolov V.1, Aksinenko A.1, Epishina T.1, Goreva T.1, Shevtsova E.1, Dubova L.1, Shevtsov P.1, Rudakova E.1, Kovaleva N.1, Makhaeva G.1, Bachurin S.1
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Afiliações:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Edição: Volume 67, Nº 11 (2018)
- Páginas: 2103-2107
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243193
- DOI: https://doi.org/10.1007/s11172-018-2335-9
- ID: 243193
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Resumo
A synthetic approach to the vinylation and allylation of tetrahydro-γ-carbolines with alkane dimethyl sulfonates in the presence of sodium hydride was developed. The effect of the synthesized 5-vinyl- and 5-allyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles on acetylcholinesterase, butyrylcholinesterase, and carboxylesterase activity, mitochondrial functions, and tubulin polymerization was investigated, and their antioxidant activity was evaluated.
Sobre autores
V. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
A. Aksinenko
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Autor responsável pela correspondência
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
T. Epishina
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
T. Goreva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
E. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
L. Dubova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
P. Shevtsov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
E. Rudakova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
N. Kovaleva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
G. Makhaeva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
S. Bachurin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
