Influence of water-soluble derivatives of [60]fullerene on catalytic activity of monoaminе oxidase B and their membranotropic properties
- Авторлар: Smolina A.1, Kotelnikova R.1, Poletaeva D.1, Troshin P.1, Khakina E.1, Zhilenkov A.1, Soldatova Y.1, Shtolko V.1, Grigoriev V.2, Bogdanov G.1, Kotelnikov A.1
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Мекемелер:
- Institute of Problems of Chemical Physics, Russian Academy of Sciencies
- Institute of Physiologically Active Compounds, Russian Academy of Sciencies
- Шығарылым: Том 65, № 3 (2016)
- Беттер: 784-789
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237633
- DOI: https://doi.org/10.1007/s11172-016-1374-3
- ID: 237633
Дәйексөз келтіру
Аннотация
The effect of two water-soluble derivatives of [60]fullerene (WS[60]FDs) on mitochondrial monoamine oxidase B (MAO-B) involved in oxidative deamination of biogenic amines has been investigated. The studied compounds were shown to be inhibitors of MAO-B. The inhibitory mechanism and the inhibition constants were determined. It was shown that WS[60]FDs I and II penetrate in lipid bilayer of membrane of phosphatidylcholine liposomes and localize in the regions of both polar head and fatty acid groups of phospholipids. The equilibrium constants of fluorescent dye—WS[60]FDs complexes were determined.
Авторлар туралы
A. Smolina
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
R. Kotelnikova
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
D. Poletaeva
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
P. Troshin
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
E. Khakina
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
A. Zhilenkov
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
Yu. Soldatova
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
V. Shtolko
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
V. Grigoriev
Institute of Physiologically Active Compounds, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
G. Bogdanov
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
A. Kotelnikov
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Хат алмасуға жауапты Автор.
Email: kotel@icp.ac.ru
Ресей, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432