Influence of water-soluble derivatives of [60]fullerene on catalytic activity of monoaminе oxidase B and their membranotropic properties
- 作者: Smolina A.1, Kotelnikova R.1, Poletaeva D.1, Troshin P.1, Khakina E.1, Zhilenkov A.1, Soldatova Y.1, Shtolko V.1, Grigoriev V.2, Bogdanov G.1, Kotelnikov A.1
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隶属关系:
- Institute of Problems of Chemical Physics, Russian Academy of Sciencies
- Institute of Physiologically Active Compounds, Russian Academy of Sciencies
- 期: 卷 65, 编号 3 (2016)
- 页面: 784-789
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237633
- DOI: https://doi.org/10.1007/s11172-016-1374-3
- ID: 237633
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详细
The effect of two water-soluble derivatives of [60]fullerene (WS[60]FDs) on mitochondrial monoamine oxidase B (MAO-B) involved in oxidative deamination of biogenic amines has been investigated. The studied compounds were shown to be inhibitors of MAO-B. The inhibitory mechanism and the inhibition constants were determined. It was shown that WS[60]FDs I and II penetrate in lipid bilayer of membrane of phosphatidylcholine liposomes and localize in the regions of both polar head and fatty acid groups of phospholipids. The equilibrium constants of fluorescent dye—WS[60]FDs complexes were determined.
作者简介
A. Smolina
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
R. Kotelnikova
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
D. Poletaeva
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
P. Troshin
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
E. Khakina
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
A. Zhilenkov
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
Yu. Soldatova
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
V. Shtolko
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
V. Grigoriev
Institute of Physiologically Active Compounds, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 Severny proezd, Chernogolovka, Moscow Region, 142432
G. Bogdanov
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432
A. Kotelnikov
Institute of Problems of Chemical Physics, Russian Academy of Sciencies
编辑信件的主要联系方式.
Email: kotel@icp.ac.ru
俄罗斯联邦, 1 prosp. Acad. Semenova, Chernogolovka, Moscow Region, 142432