Synthesis and biological activity of 3-guanidino-6-R-imidazo[1,2-b]- and 6-guanidino-3-R-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines
- Authors: Ishmetova R.I.1, Ignatenko N.K.1, Korotina A.V.1, Ganebnykh I.N.1, Slepukhin P.A.1,2, Babkova V.A.3, Gerasimova N.A.4, Evstigneeva N.P.4, Zilberberg N.V.4, Kungurov N.V.4, Rusinov G.L.1,2, Spasov A.A.3, Chupakhin O.N.1,2
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Affiliations:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Ural Research Institute of Dermatovenereology and Immunopathology
- Issue: Vol 67, No 11 (2018)
- Pages: 2079-2087
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243186
- DOI: https://doi.org/10.1007/s11172-018-2332-z
- ID: 243186
Cite item
Abstract
The reaction of azoloannulated [1,2,4,5]tetrazines with guanidine was studied. New 3-guanidinoimidazo[1,2-b]- and 6-guanidino[1,2,4]triazolo[4,3-b] [1,2,4,5]tetrazines were synthesized using the nucleophilic substitution methodology. Compounds with high antibacterial and antiglycation activity were revealed.
About the authors
R. I. Ishmetova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: iri@ios.uran.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
N. K. Ignatenko
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: iri@ios.uran.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
A. V. Korotina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: iri@ios.uran.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
I. N. Ganebnykh
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: iri@ios.uran.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
P. A. Slepukhin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: iri@ios.uran.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137; 19 ul. Mira, Yekaterinburg, 620002
V. A. Babkova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: iri@ios.uran.ru
Russian Federation, 1 pl. Pavshikh Bortsov, Volgograd, 400131
N. A. Gerasimova
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Russian Federation, 8 ul. Shcherbakova, Yekaterinburg, 620076
N. P. Evstigneeva
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Russian Federation, 8 ul. Shcherbakova, Yekaterinburg, 620076
N. V. Zilberberg
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Russian Federation, 8 ul. Shcherbakova, Yekaterinburg, 620076
N. V. Kungurov
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Russian Federation, 8 ul. Shcherbakova, Yekaterinburg, 620076
G. L. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: iri@ios.uran.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137; 19 ul. Mira, Yekaterinburg, 620002
A. A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: iri@ios.uran.ru
Russian Federation, 1 pl. Pavshikh Bortsov, Volgograd, 400131
O. N. Chupakhin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: iri@ios.uran.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137; 19 ul. Mira, Yekaterinburg, 620002