Enviar artigo por via de e-mail Synthesis and biological activity of 3-guanidino-6-R-imidazo[1,2-b]- and 6-guanidino-3-R-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines
- Autores: Ishmetova R.I.1, Ignatenko N.K.1, Korotina A.V.1, Ganebnykh I.N.1, Slepukhin P.A.1,2, Babkova V.A.3, Gerasimova N.A.4, Evstigneeva N.P.4, Zilberberg N.V.4, Kungurov N.V.4, Rusinov G.L.1,2, Spasov A.A.3, Chupakhin O.N.1,2
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Afiliações:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Ural Research Institute of Dermatovenereology and Immunopathology
- Edição: Volume 67, Nº 11 (2018)
- Páginas: 2079-2087
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243186
- DOI: https://doi.org/10.1007/s11172-018-2332-z
- ID: 243186
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Resumo
The reaction of azoloannulated [1,2,4,5]tetrazines with guanidine was studied. New 3-guanidinoimidazo[1,2-b]- and 6-guanidino[1,2,4]triazolo[4,3-b] [1,2,4,5]tetrazines were synthesized using the nucleophilic substitution methodology. Compounds with high antibacterial and antiglycation activity were revealed.
Sobre autores
R. Ishmetova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: iri@ios.uran.ru
Rússia, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
N. Ignatenko
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: iri@ios.uran.ru
Rússia, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
A. Korotina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: iri@ios.uran.ru
Rússia, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
I. Ganebnykh
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: iri@ios.uran.ru
Rússia, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137
P. Slepukhin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: iri@ios.uran.ru
Rússia, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137; 19 ul. Mira, Yekaterinburg, 620002
V. Babkova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: iri@ios.uran.ru
Rússia, 1 pl. Pavshikh Bortsov, Volgograd, 400131
N. Gerasimova
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Rússia, 8 ul. Shcherbakova, Yekaterinburg, 620076
N. Evstigneeva
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Rússia, 8 ul. Shcherbakova, Yekaterinburg, 620076
N. Zilberberg
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Rússia, 8 ul. Shcherbakova, Yekaterinburg, 620076
N. Kungurov
Ural Research Institute of Dermatovenereology and Immunopathology
Email: iri@ios.uran.ru
Rússia, 8 ul. Shcherbakova, Yekaterinburg, 620076
G. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: iri@ios.uran.ru
Rússia, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137; 19 ul. Mira, Yekaterinburg, 620002
A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: iri@ios.uran.ru
Rússia, 1 pl. Pavshikh Bortsov, Volgograd, 400131
O. Chupakhin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: iri@ios.uran.ru
Rússia, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620137; 19 ul. Mira, Yekaterinburg, 620002
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